CSScaffold in CodeIgniter

[eluser]pickupman[/eluser]
Checked out CSScaffold, and seems like a neat concept. I don't see any particular reason why they couldn't be used together. I know there are people on both sides of the fence when it comes to using CSS frameworks like 960, Blueprint, YAML etc. This takes it to a whole another level. I have used both 960 and Blueprint, and like 960 a little better, however, I don't see the need to have your stylesheets created on the fly by php. I can see the benefit of creating demos/custom frameworks for mockups, but once you have a layout complete, how often do you see changing your grid and such?