Several Domains, Different Data, One Database

[eluser]Jay Logan[/eluser]
Can it be done? My job has about 150+ domains and all they do is redirect to folders on our main web site. I want to try and utilize the keywords in them and maybe help us out with search engine results. Obviously, I don't want to make 150 different web sites. What I would like to do is create an index file that retrieves information from the DB based on the URL. I would think that I would need different cPanel accounts just to make the domains "real" in the eyes of search engines. But other than that, I'm lost. I want to try and use CI if I can but if it's overkill, forget about it. The server is a reseller cPanel account so I have limited access. Please help if you can.