If you run a site with millions of hits/ads a day you will not ask about what framework you should use ;o)
i most of all cases the normal server will serve the requests without any trouble. i never had any problems for that kind of task of all my projects and customers (since over 15 years). most trouble will be come with a wrong programming logic or bad sql queries.
For highperformance sites you will have a complete different structure from software to hardware.