[eluser]TheFuzzy0ne[/eluser]
Safe-mode can also prevent you from accessing anything outside of your Web root, which can often be a real painus in the anus.
Excerpt from the [url="http://www.php.net/manual/en/features.safe-mode.php"]PHP manual[/url]:
Quote:The PHP safe mode is an attempt to solve the shared-server security problem. It is architecturally incorrect to try to solve this problem at the PHP level, but since the alternatives at the web server and OS levels aren't very realistic, many people, especially ISP's, use safe mode for now.
So basically, if your Web host knows their stuff, the server will be secured as the OS level (with things such as chroot), and PHP safe mode will be disabled.