[eluser]Bart v B[/eluser]
Did you try also to do domain.tld/index.php/folder/folder2
What kind of server is it running?
linux or a windows system? apache webserver or lighttp or IIS?
Is the base_url right in the application/config/config.php ?
removed index.php ?
Did you make some changes in application/config/routes.php ?
Some more information would be nice to help you