Webpage Running Indefinitely?

[eluser]jamgood96[/eluser]
Is it possible to have a website run indefinitely, with ajax calls and a timer, without crashing or causing issues? Are there such things as memory leaks for websites?

I'm working on a project that the site will be displayed on a large monitor in a corridor and it will update certain values every minute, and others every hour. Can I realistically expect to leave this up and running for months on end without issues?