Connection different kind of database

Hello

I would like to create an application where the database is mysql or sqlite  (maybe other)
What is your advice for that.
can I use .env like this

#uncomment this part if you want mysql
#database.default.hostname = localhost
#database.default.database = 
#database.default.username =
#database.default.password =
#database.default.DBDriver = MySQLi

# database
database.database.database = '../writable/db/db1.db'
database.database.DBDriver = 'SQLite3'


Do you have other suggestion or idea