CI_DB_driver Bug?

In the course of using codeigniter, occasionally following error, do not know bug?

Code:

A PHP Error was encountered
Severity: Warning
Message: mysqli::real_connect(): MySQL server has gone away
Filename: mysqli/mysqli_driver.php
Line Number: 111
Backtrace:
File: D:\wwwroot\travl\application\core\MY_Controller.php
Line: 13
Function: __construct
File: D:\wwwroot\travl\application\core\MY_Controller.php
Line: 56
Function: __construct
File: D:\wwwroot\travl\application\controllers\Hotel.php
Line: 9
Function: __construct
File: D:\wwwroot\travl\index.php
Line: 282
Function: require_once