[eluser]JoostV[/eluser]
In config/routes.php, make a custom routing for every controller other than user.
Code:
$route['home/:any'] = "home";
$route['comment/:any'] = "comment";
Then, underneath those routing statements, make a route that will send all other uri's to controller users.
Code:
$route[':any'] = "users";
As long as users cannot choose a username like 'comment' or 'home', you'll be fine