MySQL use on GoDaddy.com...

[eluser]TheFuzzy0ne[/eluser]
I think that in your case, it would probably be best to keep all your eggs in one basket. I see no benefit to using more than one database, unless of course they are actually on different servers.

Essentially, what you're asking is similar to asking if it's easier to peddle a tandem on the back seat or the front. Of course, they are both the same.