routing question

[eluser]dadamssg[/eluser]
Is it possible(with CodeIgniter) to set up a site similar to twitter in that you can find different profiles at http://example.com/aporofile. I have a database full of profile users and their information but would love to instead of this

http://www.mysite.com/myfolder/profile.php?id=Bob

routed to this

http://www.mysite.com/Bob

But im not seeing how thats possible if i have folders at my root like 'myfolder' in my example. Hope that made sense!